Frontal lobes white matter abnormalities mimicking cystic leukodystrophy in Wilson’s disease

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Frontal lobes white matter abnormalities mimicking cystic leukodystrophy in Wilson's disease.

An 18-year-old male presented with a three-year history of slurred speech, gait impairment, seizures and progressive neurological deterioration. Brain MRI depicted bilateral hyperintense T2-signal in the basal ganglia and white matter abnormalities with a cystic appearance in the frontal lobes. Ophthalmological evaluation disclosed KayserFleisher rings (Figure). Ceruloplasmin was low and urinar...

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Major Superficial White Matter Abnormalities in Huntington's Disease

BACKGROUND The late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative disease effects. Therefore, it may be sensitive to ...

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Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

White matter hyperintensities as seen on brain T2-weighted magnetic resonance imaging are associated with varying degrees of cognitive dysfunction in stroke, cerebral small vessel disease and dementia. The pathophysiological mechanisms within the white matter accounting for cognitive dysfunction remain unclear. With the hypothesis that gliovascular interactions are impaired in subjects with hig...

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White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder.

UNLABELLED Antisocial personality disorder (ASPD) and psychopathy involve significant interpersonal and behavioural impairments. However, little is known about their underlying neurobiology and in particular, abnormalities in white matter (WM) microstructure. A preliminary diffusion tensor magnetic resonance imaging (DT-MRI) study of adult psychopaths employing tractography revealed abnormaliti...

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Retinothalamic White Matter Abnormalities in Amblyopia.

Purpose Amblyopia is associated with a broad array of perceptual and neural abnormalities in the visual system, particularly in untreated or unsuccessfully treated populations. Traditionally, it has been believed that the neural abnormalities are confined to the visual cortex and subcortex (e.g., lateral geniculate nucleus). Here, we investigate the presence of neuroanatomical abnormalities ear...

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ژورنال

عنوان ژورنال: Arquivos de Neuro-Psiquiatria

سال: 2017

ISSN: 0004-282X

DOI: 10.1590/0004-282x20170003